Inspired by true events, What Doesn t Kill You follows the story of two childhood friends Brian (Ruffalo) and Paulie (Hawke). The pair have grown up on the tough and unforgiving streets of South Boston doing whatever they can to survive in the dog-eat-dog neighborhood and ultimately falling under the sway of a powerful crime boss. As the vicious cycle of drugs, murder and robbery consume them the pair plan one last heist will they pull it off and escape the only life they know?