Jerry (Ryan Reynolds) is an affable singleton who works on the factory floor at a bathtub factory, ever eager to get along with his co-workers, especially Fiona (Gemma Arterton) and Lisa (Anna Kendrick) from accounts. After work Jerry goes home to his pet cat, Mr. Whiskers, and loyal dog Bosco, where the three of them hang out, watch TV and discuss the day's events. When one night he accidentally kills Fiona, Jerry hastily covers his tracks, under the strict advice of the subversive Mr. Whiskers. But Jerry is already beyond the reach of his well-meaning psychiatrist Dr. Warren (Jacki Weaver) and things are also looking bad for Lisa, who has taken a shine to Jerry. Despite Bosco trying to keep Jerry on the straight and narrow, Mr. Whiskers seems to be the loudest voice in Jerry s head and soon events have spiraled and salvation is all Jerry can hope for.