Transporting valuable human cargo of state prisoners across a hazardous war zone, a group of Interpol mercenaries headed by Agents Reyes and Milius are forced to make an unscheduled detour when they encounter the remnants of a catastrophic ecological disaster. Trapped in hazardous wasteland, miles from help and civilization, they find themselves beseiged by a vast army of rampaging, blood-thirsty mutants, ravenous creatures who will stop at nothing to devour every human in existence. As Reyes and Milius fight for their lives and to protect their precious cargo, they realize their only chance for escape is in joining forces with the treacherous criminals in their care. But these men have a past as deadly and terrifying as the monsters out for their blood.